AMPRO-500
Antibiotics
AMPRO-500
AMPRO-500 is a coccidiostat used mainly in poultry. It is a thiamine antagonist which blocks the thiamine transporter of Eimeria species and thus it interfere with the metabolism of carbohydrates in coccidia. Rapidly dividing coccidia have a high requirement for thiamine and deficiency will lead to starvation and finally to the death of coccidian cell. However, Amprolium acts on second generation of schizonts and coccidia is killed later in the life cycle. Amprolium is mainly used for water treatment during clinical outbreaks.
COMPOSITION
Each ml contains
Amprolium hydrochloride
500 mg
INDICATIONS
Treatment and prevention of coccidiosis caused by species of Eimeria susceptible to Amprolium in poultry: broilers, layers, pullets replacement, breeders (E. tenella, E. acervuline, E. necatrix etc.), turkeys (E. adenoides, E meleagridis, E. gallopavonis etc.). It might be also used as aid in treatment of coccidiosis produced by susceptible Eimeria species in calves (Eimeria zuemii, E. bovis, etc.), lambs and kids (E. ovinoidalis, E. christenseni etc.).
CONTRAINDICATIONS
Hypersensitivity to amprolium.
Dosage and administration: For oral administration in drinking water.
Poultry Treatment:- Relative normal outbreak:
25 ml per 100 liters of drinking water- Severe outbreak: 50 ml per 100 liters of drinking water Prevention of re-infection (maintenance treatment):- 10 ml per 100 liters of drinking water.
Calves, lambs, and kids
Treatment:- 2 ml per 100 kg bodyweight for 5 days (10 mg Amprolium HCl per kg bodyweight).
Prevention of re-infection (maintenance treatment):- 1 ml per 100 kg bodyweight, for 21 days (5 mg Amprolium HCl per kg bodyweight). In ruminants administration via drinking water is not considered safe, so that individual drenching is strongly recommended. Medicated water should be refreshed every 24 hours for the duration of the treatment. No other source of drinking water should be available during the period of treatment. For a correct dosage and to avoid sub therapeutic doses, the body weight should be determined with accuracy.
SIDE EFFECTS
In laying hens an egg-drop can be observed. Prolonged high dosage administration could lead to thiamine (vitamin B1) deficiency, with poorgrowth and development, gastrointestinal disturbances, loss of appetite, anorexia, muscle weakness and cramp.
PRECAUTIONS AND WARNINGS
Administered treatment should be combined with suitable animal husbandry measures. If a visible improvement is not observed after 3 days of treatment, the symptomatology picture should be reevaluated to determine evolution of other disease.
WITHDRAWAL TIMES
Poultry: Meat and offal: 0 days, Eggs: 0 days- Calves, lambs and kids: Meat and offal: 3 days
STORAGE CONDITIONS
Store in dry, dark and below 25°C. Do not freeze
PACKING
500 ml,1 litre bottles